| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 1,706,469 | $290,099,730 | 13.16% | |
| 2. | Millennium Management Israel Englander | 1,202,711 | $204,460,870 | +347% | 0.09% |
| 3. | AQR Capital Management Cliff Asness | 877,267 | $149,135,332 | +26% | 0.08% |
| 4. | Renaissance Technologies Jim Simons | 836,774 | $142,251,580 | -10% | 0.22% |
| 5. | GMT Capital Thomas E. Claugus | 638,500 | $108,545,000 | -20% | 5.66% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $103.00 | 1,621 | $166,961.54 | 101,621 | 2025-05-12 | Filing | |
| $99.71 | 100 | $9,971.00 | 100,000 | 2025-05-09 | Filing | |
| $98.91 | 19,216 | $1,900,677.62 | 99,900 | 2025-05-09 | Filing | |
| $98.10 | 80,684 | $7,915,471.55 | 80,684 | 2025-05-09 | Filing | |
| $119.65 | 12,000 | $1,435,800.00 | 27,932 | 2024-03-01 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $192.00 | 3,415 | $655,680.00 | 7,024 | 2026-02-27 | Filing | |
| $190.91 | 1,117 | $213,243.45 | 9,235 | 2026-02-27 | Filing | |
| $194.11 | 1,253 | $243,222.21 | 10,352 | 2026-02-26 | Filing | |
| $193.60 | 197 | $38,138.85 | 58,818 | 2026-02-26 | Filing | |
| $192.79 | 1,009 | $194,526.62 | 59,015 | 2026-02-26 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 5,917,142 | $1,005,914,140 | 0.01% | |
| 2. | 5,451,241 | $926,710,907 | 0.02% | |
| 3. | 2,666,602 | $453,322,340 | 0.06% | |
| 4. | 2,623,303 | $445,964,615 | 0.09% | |
| 5. | 1,837,793 | $312,424,810 | 0.01% |
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